This study was designed to demonstrate advantages of laparascpoic cholecystectomy (LC) in comparison to open cholecystectomy (OC) on the endocrine, inflammatory, and respiratory responses to surgical trauma.
21 patients with gall stone were assigned randomly to the laparoscopic cholecystectomy (N=11) or the open cholecystectomy (n=10) groups. Blood samples were obtained before the operation, 24 hours and 72 hours after the operation. Plasma
concentration of
ACTH, Cortisol, Epinephrine and Norepinephrine were measured as indices of the endocrine response. Plasma concentration of Interleukin-6(IL-6), Interleukin-1α(IL-α), tumor necrotic factor (TNF), ESR and CRP were measured as the indices of the
inflammatory response. Vital capacity (VC), Forced expiratory volum in 1s (FEV1), Functional residual capacity (FRC), pH, PaO2, PaCO2, SaO2 were measured as the indices of pulmonary function. Plasma concentrations of ACTH and cortisol in the OC
group
after the operation were increased mush more than in LC group. Plasma concentration of IL-6 in the OC group was significantly increased postoperatively, but the respiratory response show no the significant difference between the both grops.
On the bases of these results the benefit of LC was proved by the reduced endocrine and inflammatory responses to surgical trauma.
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